Development and Validation of Simple Titrimetric Method for the Determination of Magnesium Content in Esomeprazole Magnesium
نویسندگان
چکیده
A simple and inexpensive titrimetric method for the determination of magnesium ion in esomeprazole magnesium raw material was developed and validated according to International Conference on Harmonization guidelines and the United States Pharmacopoeia. The method depends on complex formation between EDTA and magnesium ion. The method was proven to be valid, equivalent and useful as an alternative method to the current pharmacopeial methods that are based on atomic absorption spectrometry.
منابع مشابه
The application of atomic absorption spectrometry for the determination of residual active pharmaceutical ingredients in cleaning validation samples.
The objective of this work was the development and validation of atomic absorption spectrometric (AAS) methods for the determination of residual active pharmaceutical ingredients (API) in rinse samples for cleaning validation. AAS as an indirect method for the determination of API in rinse samples can be applied when it is in the form of salt with metal ions or when the metal ion is a part of t...
متن کاملSolvent Extraction and Spectrophotometric Determination of Magnesium by Paratoly l-2-Thenohydroxamic Acid and Quinalizarin
Magnesium is extracted with a chloroform solution of N-p-tolyl-2- thenohydroxamic acid (PTTHA) from aqueous solution of pH 9.5 .Mg-PTTHA complex is colourless and the colour is developed by adding quinalizarin into the extract. lmax and e of the complex are 590nm and 2.8´103 Lmol -1cm-1respectively.Most common ions do not interfere in the determination of magnesi...
متن کاملA flame photometric method for the determination of plasma magnesium after hydroxyquinoline precipitation.
The numerous methods for determining magnesium in biological fluids that have been reported in the past have varied from chemical to spectrochemical techniques. Among these various procedures have been included gravimetric, calorimetric, and titrimetric techniques. The gravimetric micromethod based on the precipitation of magnesium B-hydroxyquinoline in hot ammoniacal solution, first utilized b...
متن کاملDevelopment and Validation of a Rapid Derivative Spectrophotometric Method for Determination of Tropicamide in Eye Drops
Tropicamide is an antimuscarinic agent used as eye drops for refractive examinations. The aim of this study was to develop a simple and suitable analytical method for determination of tropicamide in eye drops in the presence of excipients. A zero-crossing third and fourth derivative spectrophotometric method was described for determination of tropicamide in eye drops. The measurements wer...
متن کاملThe Effect of Environmental Parameters on the Corrosion Behavior of Simple Shear Extruded AZ91 Magnesium Alloys
In this study, the effects of forming method (extrusion) and environmental factors (solution pH and temperature) on the corrosion performance of AZ91 magnesium alloys were investigated using potentiodynamic polarization, electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM) and salt spray techniques. The polarization test results of the specimens showed that simple sh...
متن کامل